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1

Driving Cancer Dose-Response Modeling with Data, Not Assumptions

Robert L. Sielken Jr.

Journal:

Year:

1990

Language:

english

File:

PDF, 147 KB

english, 1990

2

Improving Survivability of Intelligent Transportation Systems: Application-Level Intrusion Detection Case Study

Smith, Brian L., Sielken, Robert S.

Journal:

Transportation Research Record Journal of the Transportation Research Board

Year:

2000

File:

PDF, 677 KB

2000

3

Observed versus predicted carboxyhemoglobin levels in cellulose triacetate workers exposed to methylene chloride

Jon Amsel, Kevin J. Soden, Robert L. Sielken Jr., Ciriaco Valdez-Flora

Journal:

American Journal of Industrial Medicine

Year:

2001

Language:

english

File:

PDF, 305 KB

english, 2001

4

Reconsideration of the genetic risk assessment for ethylene oxide exposures

R. Julian Preston, Timothy R. Fennell, A. Philip Leber, Robert L. Sielken Jr., James A. Swenberg

Journal:

Environmental and Molecular Mutagenesis

Year:

1995

Language:

english

File:

PDF, 1.31 MB

english, 1995

5

Generating single-unit residue concentration distributions based on maximum likelihood estimation from composite data

Ciriaco Valdez-Flores, Larry R. Holden, Robert L. Sielken Jr.

Journal:

Year:

2002

Language:

english

File:

PDF, 125 KB

english, 2002

6

Using PBPK modeling and comprehensive realism methodology for the quantitative cancer risk assessment of butadiene

Robert L. Sielken Jr., Richard H. Reitz, Scan M. Hays

Journal:

Year:

1996

Language:

english

File:

PDF, 594 KB

english, 1996

7

Stopping times for stochastic approximation procedures

Robert L. Sielken

Journal:

Probability Theory and Related Fields

Year:

1973

Language:

english

File:

PDF, 373 KB

english, 1973

8

Quantitative cancer risk assessment for ethylene oxide inhalation in occupational settings

Ciriaco Valdez-Flores, Robert L. Sielken, M. Jane Teta

Journal:

Archives of Toxicology

Year:

2011

Language:

english

File:

PDF, 1.63 MB

english, 2011

9

Addressing Nonlinearity in the Exposure-Response Relationship for a Genotoxic Carcinogen: Cancer Potency Estimates for Ethylene Oxide

C. R. Kirman, L. M. Sweeney, M. J. Teta, R. L. Sielken, C. Valdez-Flores, R. J. Albertini, M. L. Gargas

Journal:

Year:

2004

Language:

english

File:

PDF, 197 KB

english, 2004

10

A Distributional Approach to Characterizing Low-Dose Cancer Risk

John S. Evans, John D. Graham, George M. Gray, Robert L. Sielken Jr.

Journal:

Year:

1994

Language:

english

File:

PDF, 1.13 MB

english, 1994

11

Cancer Dose-Response Modeling of Epidemiological Data on Worker Exposures to Aldrin and Dieldrin

Robert L. Sielken Jr., Robert S. Bretzlaff, Ciriaco Valdez-Flores, Donald E. Stevenson, Geed de Jong

Journal:

Year:

1999

Language:

english

File:

PDF, 1.23 MB

english, 1999

12

Ethylene Oxide Cancer Risk Assessment Based on Epidemiological Data: Application of Revised Regulatory Guidelines

M. Jane Teta, Robert L. Sielken Jr., Ciriaco Valdez-Flores

Journal:

Year:

1999

Language:

english

File:

PDF, 1.50 MB

english, 1999

13

Using a nonlinear mixed effects model to characterize cholinesterase activity in rats exposed to Aldicarb

C. A. Clayton, T. B. Starr, R. L. Sielken, R. L. Williams, P. -G. Pontal, A. J. Tobia

Journal:

Journal of Agricultural, Biological, and Environmental Statistics

Year:

2003

Language:

english

File:

PDF, 1.07 MB

english, 2003

14

An approach to quantifying spatial components of exposure for ecological risk assessment

Philip A. Clifford, David F. Ludwig, Daniel E. Barchers, J. Scott Klingensmith, Richard V. Graham, Robert L. Sielken, Marcy I. Banton

Journal:

Environmental Toxicology and Chemistry

Year:

1995

Language:

english

File:

PDF, 1.28 MB

english, 1995

15

Cancer risk assessment for 1,3-butadiene: Dose–response modeling from an epidemiological perspective

Robert L. Sielken Jr., Ciriaco Valdez-Flores, Michael L. Gargas, Christopher R. Kirman, M. Jane Teta, Elizabeth Delzell

Journal:

Chemico-Biological Interactions

Year:

2007

Language:

english

File:

PDF, 221 KB

english, 2007

16

Life-table calculations of excess risk for incidence versus mortality: Ethylene oxide case study

Robert L. Sielken Jr., Ciriaco Valdez-Flores

Journal:

Regulatory Toxicology and Pharmacology

Year:

2009

Language:

english

File:

PDF, 582 KB

english, 2009

17

Calculating excess risk with age-dependent adjustment factors and cumulative doses: Ethylene oxide case study

Robert L. Sielken, Ciriaco Valdez Flores

Journal:

Regulatory Toxicology and Pharmacology

Year:

2009

Language:

english

File:

PDF, 315 KB

english, 2009

18

Quantitative cancer risk assessment based on NIOSH and UCC epidemiological data for workers exposed to ethylene oxide

Ciriaco Valdez-Flores, Robert L. Sielken Jr., M. Jane Teta

Journal:

Regulatory Toxicology and Pharmacology

Year:

2010

Language:

english

File:

PDF, 307 KB

english, 2010

19

Butadiene cancer exposure–response modeling: Based on workers in the styrene–butadiene–rubber industry: Total leukemia, acute myelogenous leukemia, chronic lymphocytic leukemia, and chronic myelogenous leukemia

Robert L. Sielken Jr., Ciriaco Valdez-Flores

Journal:

Regulatory Toxicology and Pharmacology

Year:

2011

Language:

english

File:

PDF, 931 KB

english, 2011

20

Development of a unit risk factor for nickel and inorganic nickel compounds based on an updated carcinogenic toxicity assessment

Joseph T. Haney Jr., Darrell D. McCant, Robert L. Sielken Jr., Ciriaco Valdez-Flores, Roberta L. Grant

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 401 KB

english, 2012

21

Dose–response implications of the University of Alabama study of lymphohematopoietic cancer among workers exposed to 1,3-butadiene and styrene in the synthetic rubber industry

Robert L. Sielken Jr, Ciriaco Valdez-Flores

Journal:

Chemico-Biological Interactions

Year:

2001

Language:

english

File:

PDF, 216 KB

english, 2001

22

Ethylene Oxide Cancer Risk Assessment Based on Epidemiological Data: Application of Revised Regulatory Guidelines

M. Jane Teta, Robert L. Sielken, Ciriaco Valdez-Flores

Journal:

Year:

1999

Language:

english

File:

PDF, 189 KB

english, 1999

23

Cancer Dose-Response Modeling of Epidemiological Data on Worker Exposures to Aldrin and Dieldrin

Robert L. Sielken, Robert S. Bretzlaff, Ciriaco Valdez-Flores, Donald E. Stevenson, Geert de Jong

Journal:

Year:

1999

Language:

english

File:

PDF, 125 KB

english, 1999

24

Oncogenicity Testing of 2-Ethylhexanol in Fischer 344 Rats and B6C3F1 Mice

B.D. Astill, R. Gingell, D. Guest, J. Hellwig, J.R. Hodgson, K. Kuettler, W. Mellert, S.R. Murphy, R.L. Sielken Jr., T.R. Tyler

Journal:

Fundamental and Applied Toxicology

Year:

1996

Language:

english

File:

PDF, 170 KB

english, 1996

25

Another Flaw in the Linearized Multistage Model Upper Bounds on Human Cancer Potency

R.L. Sielken, D.E. Stevenson

Journal:

Regulatory Toxicology and Pharmacology

Year:

1994

File:

PDF, 479 KB

1994

26

Use of Probabilistic Expert Judgment in Uncertainty Analysis of Carcinogenic Potency

J.S. Evans, G.M. Gray, R.L. Sielken, A.E. Smith, C. Valdezflores, J.D. Graham

Journal:

Regulatory Toxicology and Pharmacology

Year:

1994

File:

PDF, 1.22 MB

1994

27

Challenges to Default Assumptions Stimulate Comprehensive Realism as a New Tier in Quantitative Cancer Risk Assessment

R.L. Sielken, R.S. Bretzlaff, D.E. Stevenson

Journal:

Regulatory Toxicology and Pharmacology

Year:

1995

File:

PDF, 1.02 MB

1995

28

Overestimation Bias and Other Pitfalls Associated with the Estimated 99.9th Percentile in Acute Dietary Exposure Assessments

Christine F. Chaisson, Robert L. Sielken Jr., Darin K. Waylett

Journal:

Regulatory Toxicology and Pharmacology

Year:

1999

Language:

english

File:

PDF, 224 KB

english, 1999

29

Risk Metrics and Cumulative Risk Assessment Methodology for the FQPA

Robert L. Sielken Jr.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2000

Language:

english

File:

PDF, 82 KB

english, 2000

30

Probabilistic risk assessment's use of trees and distributions to reflect uncertainty and variability and to overcome the limitations of default assumptions

R.L. Sielken Jr., C. Valdez-Flores

Journal:

Environment International

Year:

1999

Language:

english

File:

PDF, 1.79 MB

english, 1999

31

An updated inhalation unit risk factor for arsenic and inorganic arsenic compounds based on a combined analysis of epidemiology studies

Erraguntla, Neeraja K., Sielken, Robert L., Valdez-Flores, Ciriaco, Grant, Roberta L.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 292 KB

english, 2012

32

Development of a cancer-based chronic inhalation reference value for hexavalent chromium based on a nonlinear-threshold carcinogenic assessment

Haney, Joseph T., Erraguntla, Neeraja, Sielken, Robert L., Valdez-Flores, Ciriaco

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 318 KB

english, 2012

33

Statistical evaluations reflecting the skewness in the distribution of TCDD levels in human adipose tissue

Robert L. Sielken Jr.

Journal:

Year:

1987

Language:

english

File:

PDF, 209 KB

english, 1987

34

Monograph: Reassessment of human cancer risk of aldrin/dieldrin

Donald E Stevenson, Earl F Walborg Jr, D Warner North, Robert L Sielken Jr, C.E Ross, Alan S Wright, Yong Xu, Lisa M Kamendulis, James E Klaunig

Journal:

Toxicology Letters

Year:

1999

Language:

english

File:

PDF, 447 KB

english, 1999

35

Assessment of safety/risk of chemicals: inception and evolution of the ADI and dose-response modeling procedures

Lu, Frank C., Sielken, Robert L.

Journal:

Toxicology Letters

Year:

1991

Language:

english

File:

PDF, 2.83 MB

english, 1991

36

A "Super-Population Viewpoint" for Finite Population Sampling

H. O. Hartley and R. L. Sielken, Jr.

Journal:

Year:

1975

Language:

english

File:

PDF, 933 KB

english, 1975

37

Quantitative cancer risk assessments for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Sielken Jr, R.L.

Journal:

Food and Chemical Toxicology

Year:

1987

Language:

english

File:

PDF, 838 KB

english, 1987

38

Misinterpretation of categorical rate ratios and inappropriate exposure–response model fitting can lead to biased estimates of risk: Ethylene oxide case study

Valdez-Flores, Ciriaco, Sielken, Robert L.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.14 MB

english, 2013

39

Development of an inhalation unit risk factor for hexavalent chromium

Haney, Joseph T., Erraguntla, Neeraja, Sielken, Robert L., Valdez-Flores, Ciriaco

Journal:

Regulatory Toxicology and Pharmacology

Year:

2014

Language:

english

File:

PDF, 521 KB

english, 2014

40

A comparison of statistical methods for low dose extrapolation utilizing time-to-tumor data

KREWSKI, D, CRUMP, K, FARMER, J, GAYLOR, D, HOWE, R, PORTIER, C, SALSBURG, D, SIELKEN, R, VANRYZIN, J

Journal:

Fundamental and Applied Toxicology

Year:

1983

Language:

english

File:

PDF, 1.86 MB

english, 1983

41

Quantitative risk assessment of exposures to butadiene in EU occupational settings based on the University of Alabama at Birmingham epidemiological study

Sielken, Robert L., Valdez-Flores, Ciriaco

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.95 MB

english, 2013

42

Some issues in the quantitative modeling portion of cancer risk assessment

Sielken, Robert L.

Journal:

Regulatory Toxicology and Pharmacology

Year:

1985

Language:

english

File:

PDF, 523 KB

english, 1985

43

Supplement 1 || Modeling to Incorporate Defense Mechanisms into the Estimation of Dose Responses

Robert L. Sielken, Jr. and Donald E. Stevenson

Journal:

Environmental Health Perspectives

Year:

1998

Language:

english

File:

PDF, 656 KB

english, 1998

44

Variance Estimation Based on a Superpopulation Model in Two-Stage Sampling

Richard K. Burdick and Robert L. Sielken, Jr.

Journal:

Journal of the American Statistical Association

Year:

1979

Language:

english

File:

PDF, 554 KB

english, 1979

45

Two Linear Programming Algorithms for Unbiased Estimation of Linear Models

R. L. Sielken, Jr. and H. O. Hartley

Journal:

Journal of the American Statistical Association

Year:

1973

Language:

english

File:

PDF, 688 KB

english, 1973

46

Exact Confidence Intervals for Linear Combinations of Variance Components in Nested Classifications

Richard K. Burdick and Robert L. Sielken, Jr.

Journal:

Journal of the American Statistical Association

Year:

1978

Language:

english

File:

PDF, 573 KB

english, 1978

47

Estimating the distribution function of a transformed random vector

Baker, Thomas C., Sielken, Robert L

Journal:

Communications in Statistics - Simulation and Computation

Year:

1981

Language:

english

File:

PDF, 446 KB

english, 1981

48

Updated Mortality Analyses of Pernis Epidemiological Data on Human Exposures to Aldrin and Dieldrin

Sielken,, Robert L., Bretzlaff, Robert S., Stevenson, Donald E., Jong, Geert de

Journal:

Human and Ecological Risk Assessment An International Journal

Year:

1998

Language:

english

File:

PDF, 193 KB

english, 1998

49

Multiyear, through the season crop acreage estimation using estimated acreage in sample segments

Sielken, Robert L, Gbur, Edward E

Journal:

Communication in Statistics- Theory and Methods

Year:

1984

Language:

english

File:

PDF, 470 KB

english, 1984

50

Two Linear Programming Algorithms for Unbiased Estimation of Linear Models

Sielken, R. L., Hartley, H. O.

Journal:

Journal of the American Statistical Association

Year:

1973

Language:

english

File:

PDF, 300 KB

english, 1973